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CleanScribe RNA Polymerase is designed to reduce the formation of double-stranded RNA (dsRNA) during in vitro transcription (IVT) of mRNA.
September 24, 2024
By: Charlie Sternberg
Associate Editor
Maravai LifeSciences subsidiaries TriLink BioTechnologies and Alphazyme have jointly introduced CleanScribe RNA Polymerase, a novel enzyme designed to significantly reduce the formation of double-stranded RNA (dsRNA) during in vitro transcription (IVT) of mRNA. This innovation aims to enhance the safety and efficacy of mRNA-based therapeutics. dsRNA is an unwanted byproduct of IVT that can trigger adverse inflammatory responses in host cells. CleanScribe RNA Polymerase, a novel DNA-dependent...
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